MATERIAL SAFETY DATA SHEET

	Date-Issued:   02/06/1995 MSDS Ref. No:   PSMSD-858 Date-Revised:   05/01/1998 Revision No:   3
Tetraisopropyl Methylenediphosphonate

1. PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME:  Tetraisopropyl Methylenediphosphonate

GENERAL USE:  Pharmaceutical Intermediate (For Export Use Only)

PRODUCT CODE:  858

PRODUCT FORMULATION NAME:  Phosphonic Acid,1,1-Methylenebis-Tetrakis (1-Methylethyl) Ester

CHEMICAL FAMILY:  Dialkyl Alkyl Phosphonate

GENERIC NAME:  Tetraisopropyl Methylenediphosphonate

COMMENTS: To the best of our knowledge, this Material Safety Data Sheet conforms to the requirements of US OSHA 29 CFR 1910.1200, 91/155/EEC and Canadian Hazardous Products Act.

2. COMPOSITION / INFORMATION ON INGREDIENTS

EEC LABEL SYMBOL AND CLASSIFICATION

R 21: Harmful in contact with skin. R 22: Harmful if swallowed. R 36: Irritating to eyes.

EEC Harmful - "Xn"

COMMENTS: Product composition ranges shown are typical values for health, safety and environmental use and are not intended as specifications.

3. HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW

PHYSICAL APPEARANCE: Clear and colorless organic liquid with characteristic odor.

POTENTIAL HEALTH EFFECTS

EYES: May cause significant irritation to the eyes.

SKIN: Not expected to cause significant irritation to the skin.

INGESTION: Not expected to cause significant irritation of the digestive tract.

INHALATION: Not expected to cause significant irritation of the lungs, upper respiratory tract or nose.

SIGNS AND SYMPTOMS OF OVEREXPOSURE

EYES: Redness and possible itching and/or tearing of the eyes.

SKIN: Possible redness and/or itching of the skin.

INGESTION: Possible nausea and/or vomiting.

INHALATION: Possible coughing, burning, tightness of chest and/or shortness of breath.

ACUTE TOXICITY: May cause significant adverse effects if absorbed through the skin. May cause significant adverse effects if ingested. No test data is available for acute inhalation toxicity.

CARCINOGENICITY: Not Listed by NTP Not listed by IARC Not listed by OSHA

MUTAGENICITY: This product was tested to be positive in a laboratory test tube study.

REPRODUCTIVE TOXICITY

REPRODUCTIVE EFFECTS: Not Available

TERATOGENIC EFFECTS: Not Available

MEDICAL CONDITIONS AGGRAVATED: None known.

TARGET ORGAN STATEMENT: Not Applicable

SENSITIZATION: Not Applicable

COMMENTS: For detailed toxicological information see Section 11.

4. FIRST AID MEASURES

EYES: Immediately flush eyes with plenty of water for two to three minutes. Remove any contact lenses and continue flushing for 15 minutes. Get medical attention.

SKIN: Remove contaminated clothing including shoes and wash skin with plenty of soap and water. If irritation occurs, seek medical advice. Wash contaminated clothing and shoes before reuse.

INGESTION: Wash out mouth with water and keep at rest. Seek medical attention.

INHALATION: Remove from further exposure. Keep warm and at rest. If cough or other symptoms develop, seek medical attention.

5. FIRE FIGHTING MEASURES

FLASHPOINT AND METHOD: 160°C (320°F) CC

FLAMMABLE LIMITS: Not Available

AUTOIGNITION TEMPERATURE: Not Available

FLAMMABLE CLASS: Nonflammable

FLAME PROPAGATION OR BURNING RATE OF SOLIDS: Not Applicable

GENERAL HAZARD: Evacuate personnel downwind of fire to avoid inhalation of irritating and/or harmful fumes and smoke.

EXTINGUISHING MEDIA: Chemical type foam, CO2 (Carbon Dioxide), Dry Chemical, Water Fog

HAZARDOUS COMBUSTION PRODUCTS: Oxides of both carbon and phosphorus

FIRE FIGHTING PROCEDURES: For small containers of organic substances, it should be considered if there will be less damage by allowing the material to burn to exhaustion rather than fighting the fire and risk causing environmental contamination and other problems.

FIRE FIGHTING EQUIPMENT: Respiratory and eye protection are required for fire fighting personnel. Full protective equipment (Bunker Gear) and self contained breathing apparatus (SCBA) should be used for all indoor fires and any significant outdoor fires. For small outdoor fires, which may easily be extinguished with a portable fire extinguisher, use of a SCBA may not be required.

SENSITIVE TO STATIC DISCHARGE: Not Available

SENSITIVITY TO IMPACT: Not Available

6. ACCIDENTAL RELEASE MEASURES

SMALL SPILL: Construct temporary dikes of dirt, sand, or any appropriate readily available material to prevent spreading of the material. Wearing the appropriate personal protective equipment designated in Section 8, move the leaking container to a containment area or rotate the container so that the opening is above the liquid level. Absorb on diatomaceous earth or equivalent inert material. Shovel up and dispose of at an appropriate waste disposal facility according to current applicable laws and regulations, and product characteristics at time of disposal.

LARGE SPILL: Construct temporary dikes of dirt, sand, or any appropriate readily available material to prevent spreading of the material. Wearing the appropriate personal protective equipment designated in Section 8, close or cap valves and/or block or plug hole in leaking container and transfer to another container. Contain material as described above and call the local fire or police department for immediate emergency assistance.

ENVIRONMENTAL PRECAUTIONS

WATER SPILL: Use appropriate containment to avoid runoff or release to sewer or waterways.

LAND SPILL: Use appropriate containment to avoid runoff or release to ground.

GENERAL PROCEDURES: Remove containers of strong oxidizers and strong bases from release area.

RELEASE NOTES: If spill could potentially enter any waterway, including intermittent dry creeks, contact the local authorities. If in the U.S., contact the US COAST GUARD NATIONAL RESPONSE CENTER toll free number 800-424-8802. In case of accident or road spill notify: CHEMTREC in USA at 800-424-9300 CANUTEC in Canada at 613-996-6666 CHEMTREC, other countries, at (International code)+1 703 527 3887

COMMENTS: See Section 13 for disposal information and Section 15 for regulatory requirements. Large and small spills may have a broad definition depending on the user's handling system. Therefore, the spill category must be defined at the point of release by technically qualified personnel.

7. HANDLING AND STORAGE

HANDLING: Use appropriate personal protective equipment as specified in Section 8. Handle in a well ventilated area. Handle and use in a manner consistent with good industrial/manufacturing techniques and practices.

STORAGE: Store in unopened containers under cool and dry conditions. Do not store with, or close to oxidizers and bases.

8. EXPOSURE CONTROLS / PERSONAL PROTECTION

EXPOSURE GUIDELINES:

OSHA HAZARDOUS COMPONENTS (29 CFR 1910.1200)

		EXPOSURE LIMITS
Chemical Name		OSHA PEL		ACGIH TLV		Supplier OEL
		ppm	mg/m3	ppm	mg/m3	ppm	mg/m3
Phosphonic acid, bis(1-methylethyl) ester	TWA	NL ppm[1]	NL mg/m3	NL ppm	NL mg/m3	NL ppm	NL mg/m3
	STEL	NL ppm	NL mg/m3	NL ppm	NL mg/m3	NL ppm	NL mg/m3

OSHA TABLE COMMENTS:
1. NL = Not Listed

ENGINEERING CONTROLS: Good ventilation should be sufficient to control airborne levels of material.

PERSONAL PROTECTIVE EQUIPMENT

EYES AND FACE: Wear safety glasses with side shields or goggles when handling this material.

SKIN: To prevent any contact, wear impervious protective clothing such as neoprene or butyl rubber gloves, apron, boots or whole bodysuit, as appropriate.

RESPIRATORY: Always wear NIOSH approved respiratory protective equipment when vapor or mists may exceed applicable concentration limits.

WORK HYGIENIC PRACTICES: Facilities storing or using this material should be equipped with an eyewash facility and a safety shower. Good personal hygiene practices should always be followed.

COMMENTS: This product contains no known OSHA hazardous ingredients per 29 CFR 1910.1200. No PEL's, TLV's or OEL's for this product or it's ingredients are listed in the current issue of ACGIH's Guide to Occupational Exposure Values nor have they been determined by the manufacturer.

9. PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE: Liquid

ODOR: Characteristic

APPEARANCE: Clear

COLOR: Colorless

pH: Not Applicable

VAPOR PRESSURE: Not Available

VAPOR DENSITY: Not Available

BOILING POINT: 150°C (302°F)

FREEZING POINT: Not Available

MELTING POINT: Not Available

SOLUBILITY IN WATER: Infinitely soluble

EVAPORATION RATE: Not Available

DENSITY: 1.07 g/ml at 59°C (15°F)

SPECIFIC GRAVITY: 1.07 @ 15°C/4°C

VISCOSITY: 25Centipoise at 25°C (77°F)

MOLECULAR FORMULA: C₁₃H₃₀O₆P₂

MOLECULAR WEIGHT: 344.4 g/gmol

COEFF. OIL/WATER: Not Available

10. STABILITY AND REACTIVITY

STABLE: YES

HAZARDOUS POLYMERIZATION: NO

CONDITIONS TO AVOID: Heat.

STABILITY: The product is stable under normal ambient conditions of temperature and pressure.

POLYMERIZATION: Will not occur

HAZARDOUS DECOMPOSITION PRODUCTS: Oxides of both phosphorus and carbon and acids of phosphorus.

INCOMPATIBLE MATERIALS: Strong Oxidizers

11. TOXICOLOGICAL INFORMATION

ACUTE

DERMAL LD₅₀: 1000 mg/kg (rabbit)

ORAL LD₅₀: 500 mg/kg (rat)

INHALATION LC₅₀: Not Available

EYE EFFECTS: This material may cause significant irritation to the eyes.

SKIN EFFECTS: This material is not expected to cause significant irritation to the skin.

SENSITIZATION: Not Available

TARGET ORGANS: Eyes

CARCINOGENICITY:

IARC: Listed by IARC - No

NTP: Listed by NTP - No

OSHA: Listed by OSHA - No

MUTAGENICITY: Positive in the Mouse Lymphoma with activation.

REPRODUCTIVE EFFECTS: Not Available

TERATOGENIC EFFECTS: Not Available

GENERAL COMMENTS: Chemical analogs of this material are reported to lower blood cholinesterase activity moderately.

12. ECOLOGICAL INFORMATION

ENVIRONMENTAL DATA: May cause adverse environmental impact if material reaches waterways.

ECOTOXICOLOGICAL INFORMATION: Not Available

DISTRIBUTION: Not Available

CHEMICAL FATE INFORMATION: Not Available

13. DISPOSAL CONSIDERATIONS

DISPOSAL METHOD: Dispose of waste at an appropriate waste disposal facility according to current applicable laws and regulations.

FOR LARGE SPILLS: Contain material and call local authorities for emergency assistance. In consultation with the appropriate authorities, determine the disposal method or contact Albright & Wilson Americas.

PRODUCT DISPOSAL: Dispose of at a supervised incineration facility or an appropriate waste disposal facility according to current applicable laws and regulations and product characteristics at time of disposal.

EMPTY CONTAINER: Rinse drums with a suitable solvent and steam to remove vapors before disposal or reuse in accordance with applicable regulations.

GENERAL COMMENTS: Refer to Section 6, Accidental Release Measures for additional information.

14. TRANSPORT INFORMATION

DOT (DEPARTMENT OF TRANSPORTATION)

PROPER SHIPPING NAME: Not restricted by DOT

TECHNICAL NAME: Tetraisopropyl Methylenediphosphonate

LABEL: Use Product Identifier, "Trade Name", with technical name below.

CANADA TRANSPORT OF DANGEROUS GOODS

PROPER SHIPPING NAME: Not restricted

LABEL: Use Product Identifier, "Trade Name", with technical name below.

AIR (ICAO/IATA)

PROPER SHIPPING NAME: Not restricted

LABEL: Use Product Identifier, "Trade Name", with technical name below.

VESSEL (IMO/IMDG)

PROPER SHIPPING NAME: Not restricted

LABEL: Use Product Identifier, "Trade Name", with technical name below.

EUROPEAN TRANSPORTATION:

ADR/RID HAZARD CLASSIFICATION: Not Regulated

U.S. CUSTOMS HARMONIZATION NUMBER: 2919.00.50.50

15. REGULATORY INFORMATION

UNITED STATES

SARA TITLE III (SUPERFUND AMENDMENTS AND REAUTHORIZATION ACT)

311/312 HAZARD CATEGORIES:

FIRE: NO   PRESSURE GENERATING: NO   REACTIVITY: NO   ACUTE: NO   CHRONIC: NO  

313 REPORTABLE INGREDIENTS: Not Applicable

TITLE III NOTES: Not Applicable

CERCLA (COMPREHENSIVE RESPONSE, COMPENSATION, AND LIABILITY ACT)

CERCLA RQ: Not Applicable

TSCA (TOXIC SUBSTANCE CONTROL ACT)

TSCA REGULATORY: All intentional ingredients are listed on the TSCA Inventory.

NATIONAL RESPONSE CENTER: U.S. Coast Guard National Center telephone # 1-800-424-8802

CANADA

WHMIS HAZARD SYMBOL AND CLASSIFICATION

Class D, Division 2, Subdivision B: Toxic Material May cause eye irritation.

WHMIS Toxic

WHMIS (WORKER HAZARDOUS MATERIALS INFORMATION SYSTEM): This product is WHMIS controlled.

CANADA INGREDIENT DISCLOSURE LIST: This product does not contain any known ingredient(s) on the "Ingredient Disclosure List".

CANADIAN ENVIRONMENTAL PROTECTION ACT: All intentional ingredients are not listed on the DSL (Domestic Substances List).

EUROPEAN COMMUNITY

EEC LABEL SYMBOL AND CLASSIFICATION

R 21: Harmful in contact with skin. R 22: Harmful if swallowed. R 36: Irritating to eyes. S 25: Avoid contact with eyes. S 26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36: Wear suitable protective clothing. S 46: If swallowed, seek medical advice immediately and show this container or label.

EEC Harmful - "Xn"

EUROPEAN COMMUNITY REGULATORY: All intentional ingredients are listed on the European's EINECS Inventory.

MEXICO This product is considered to be an irritant according to Mexican Standard, Instruction No. 9, ANNEX 1.

STATE REGULATIONS Not Available

REGULATIONS

STATE REGULATIONS: Not Available

LOCAL REGULATIONS: Not Available

16. OTHER INFORMATION

REASON FOR ISSUE: New format with additional information.

APPROVED BY: Paul R. Larson      TITLE:  Product Stewardship Manager

PREPARED BY: Product Stewardship Department

INFORMATION CONTACT: Product Stewardship Analyst

REVISION SUMMARY Revision #: 3 This MSDS replaces the November 7, 1997 MSDS. Any changes in information are as follows: In Section 3 Emergency Overview - Immediate Concerns (text) In Section 15 TSCA Status - (text)

DATA SOURCES: Acute Oral LD50 (rat), MB89-9672A, 1989 Acute Dermal LD50 (rabbit), MB93-2876B, 1993 Eye Irritation, MB93-2876D Dermal Irritation, MB92-2015C Mutagenicity, Mouse Lymphoma, Genesys Research, Inc., Study # 96058, 1996 Product Health Hazard Review by Consultant Toxicologist, Dr. R. V. Blanke

MANUFACTURER DISCLAIMER: Information given herein is offered in good faith as accurate, but without guarantee. Conditions of use and suitability of the product for particular uses are beyond our control; all risks of use of the product are therefore assumed by the user. Nothing is intended as a recommendation for uses which infringe valid patents or as extending license under valid patents. Appropriate warnings and safe handling procedures should be provided to handlers and users.